Selected Publications:

  1. Cabel CR, Alizadeh E, Robbins DJ, Ahmed Y, Lee E, and Thorne CA (2019). Single cell analyses confirm the critical role of LRP6 for Wnt signaling in APC-deficient cells. Developmental Cell, accepted

  2. Tian A, Duwadi D, Benchabane H, and Ahmed Y (2019). Essential long-range action of Wingless/Wnt in adult intestinal compartmentalization. PLoS Genetics 15: e1008111. [Link]

    · Featured in: Steward RA, Ramakrishnan, A-B, and Cadigan KM (2019). Diffusion and function of Wnt ligands. PLoS Genetics 15: e1008154.

  3. Wang Z, Tacchelly-Benites O, Noble GP, Johnson MK, Gagné J-P, Poirier GG, and Ahmed Y (2019). A context-dependent role for the RNF146 ubiquitin ligase in Wingless/Wnt signaling in Drosophila. Genetics 211: 913-923. [Link]

  4. Neitzel LR, Spencer ZT, Nayak A, Cselenyi CS, Benchabane H, Youngblood CQ, Zouaoui A, Ng V, Stephens L, Hann T, Patton JG, Robbins D, Ahmed Y, and Lee E (2019) Developmental regulation of Wnt signaling by Nagk and the UDP-GlcNAc salvage pathway. Mech Dev 156:20-31. [Link]

  5. Tacchelly-Benites O, Wang Z, Yang E, Benchabane H, Tian A, Randall MP and Ahmed Y (2018). Axin phosphorylation in both Wnt-Off and Wnt-On states requires the tumor suppressor APC. PLOS Genetics 14: e1007178. [Link]

  6. Tian A, Benchabane H, and Ahmed Y (2018) Wingless/Wnt signaling in intestinal homeostasis and tumorigenesis: a Drosophila perspective. J. Dev Biol 6: E8. [Link]

  7. Saito-Diaz K, Benchabane H, Tiwari A, Tian A, Li B, Hyde AS, Sawyer LM, Jodoin JN, Santos E, Lee LA, Coffey RJ, Beauchamp RD, Kenworthy A, Robbins DJ, Ahmed Y*, and Lee E* (2018). APC inhibits ligand-independent Wnt signaling by the clathrin endocytic pathway. Developmental Cell 44: 566-581 (*co-corresponding authors). [Link]

    · Featured in: McGough IJ and Vincent JP (2018). APC moonlights to prevent Wnt signalosome assembly. Developmental Cell 44: 535-7.

  8. Tian A, Benchabane H, Wang Z, Zimmerman C, Xin N, Perochon J, Kalna G, Sansom OJ, Cheng C, Cordero JB, and Ahmed Y (2017). Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect Wing. PLOS Genetics 13: e1006870. [Link]

  9. Tian A, Benchabane H, Wang Z, and Ahmed Y (2016). Regulation of stem cell proliferation and cell fate specification by Wingless/Wnt signaling gradients enriched at adult intestinal compartment boundaries. PLoS Genetics 12: e1005822. [Link]

  10. Yang E, Tacchelly-Benites O, Wang Z, Randall MP, Tian A, Benchabane H, Freemantle S, Pikielny C, Tolwinski NS, Lee E, and Ahmed Y (2016). Wnt pathway activation by ADP-ribosylation. Nature Communications 7:11430 [Link]

  11. Wang Z, Tian A, Benchabane H, Tacchelly-Benites O, Yang E, Nojima H, and Ahmed Y (2016). The ADP-Ribose Polymerase Tankyrase Regulates Adult Intestinal Stem Cell Proliferation During Homeostasis in Drosophila. Development 143: 1710. [Link]

  12. Wang Z, Tacchelly-Benites O, Yang E, Thorne CA, Nojima H, Lee E and Ahmed Y (2016). Wingless/Wnt pathway activation is promoted by a critical threshold of Axin maintained by the APC tumor suppressor and the ADP-ribose polymerase Tankyrase. Genetics 115: 183244. [Link]

  13. Wang Z, Tacchelly-Benites O, Yang E, and Ahmed Y (2016). Dual roles for membrane association of Drosophila Axin in Wnt signaling. PLOS Genetics 12: e1006494. [Link]

  14. Lebensohn AM, Dubey R, Neitzel LR, Tacchelly-Benites O, Yang E, Marceau CD, Ma Y, Davis EM, Patel BB, Bahrami-Nejad Z, Ahmed Y, Lee E, Carette J and Rohatgi R (2016). Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling. eLife 10.7554/eLife.21459 [Link]